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TBK1 抗体 (pSer172)

Name: TBK1 抗体 (pSer172)
SKU: ABIN746363
Availability: OutOfStock

TBK1 适用: 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated

DEF cells were treated as described in Figure 6A, and cells were harvested for Western blot analysis and immunoblotted for p-TBK1 (ABIN746363), p62, Flag, DTMUV-E, and beta-actin. (TBK1 抗体 (pSer172))

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Phospho-TBK1/NAK (Ser172) Polyclonal Antibody, Unconjugated (ABIN746363) at 1:200 followed by conjugation to the secondary antibody and DAB staining (TBK1 抗体 (pSer172))

IHC

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-TBK1 (Ser172) Polyclonal Antibody, Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining (TBK1 抗体 (pSer172))

IHC (p)

DEF cells were mock-infected or infected with DTMUV at an MOI of 1 for 24 and 48 h. (TBK1 抗体 (pSer172))

4 images

(3 references)

产品编号 ABIN746363

发货至: 中国

Datasheet as PDF

抗原 See all TBK1 抗体

TBK1 (TANK-Binding Kinase 1 (TBK1))
抗原表位
10

9

8

7

6

6

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
pSer172
适用
71

50

28

6

6

6

5

5

5

4

3

2

2

1

1

1

1

1
小鼠, 大鼠, 猴
宿主
73

11

1
兔
Compatible Secondaries
克隆类型
72

13
多克隆
标记
45

8

8

6

3

3

2

2

2

2

2

2
This TBK1 antibody is un-conjugated
应用范围
57

43

26

10

8

6

3

2

2

1
Western Blotting (WB)

特异性

This phosphorylation site is homologous across the listed species.

交叉反应

人, 小鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172

亚型

IgG

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anti-TANK-Binding Kinase 1 (TBK1) (AA 9-310) antibody
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anti-TANK-Binding Kinase 1 (TBK1) (AA 150-181) antibody
TBK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB16573 unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 364-585) antibody
TBK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (C-Term) antibody
TBK1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 644-661) antibody
TBK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 74-123) antibody
TBK1 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴, Pig, 兔, 马, 豚鼠, 斑马鱼, Hamster, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (Internal Region) antibody
TBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 514-527) antibody
Verified TBK1 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Hu, Pan, Cheng, Zhang, Wang, Chen, Zhu, Liu, Yang, Wu, Zhao, Huang, Zhang, Mao, Ou, Yu, Zhang, Liu, Tian, Pan, Rehman, Yin, Jia: "Autophagy Promotes Duck Tembusu Virus Replication by Suppressing p62/SQSTM1-Mediated Innate Immune Responses In Vitro." in: Vaccines, Vol. 8, Issue 1, (2020) (PubMed).

Wan, Chen, Li, Pang, Chen, Nie, Pan, Qiao, Bao: "Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction." in: International journal of biological macromolecules, Vol. 138, pp. 198-206, (2020) (PubMed).

Takahashi, Loo, Okada, Kamachi, Watanabe, Wakita, Watanabe, Kawamoto, Miyata, Barber, Ohtani, Hara: "Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells." in: Nature communications, Vol. 9, Issue 1, pp. 1249, (2018) (PubMed).
抗原

TBK1 (TANK-Binding Kinase 1 (TBK1))

别名

TBK1 (TBK1 产品)

别名

nak antibody, t2k antibody, TBK1 antibody, wu:fk70c05 antibody, zgc:136548 antibody, NAK antibody, T2K antibody, 1200008B05Rik antibody, AI462036 antibody, AW048562 antibody, TANK binding kinase 1 L homeolog antibody, TANK binding kinase 1 antibody, TANK-binding kinase 1 antibody, tbk1.L antibody, TBK1 antibody, tbk1 antibody, Tbk1 antibody

背景

Synonyms: NAK, T2K, Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, TANK-binding kinase 1, TBK1
Background: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

基因ID

29110

UniProt

Q9UHD2

途径

TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome