RPS6KA3 抗体 (pSer227)
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- 抗原 See all RPS6KA3 抗体
- RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))
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抗原表位
- pSer227
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RPS6KA3 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody will cross react with Ribosomal protein S6 kinase alpha-1 when phosphorylated at Ser221 and Ribosomal protein S6 kinase alpha-6 at Ser232.
- 交叉反应
- 人, 大鼠
- 预测反应
- Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human RSK2 around the phosphorylation site of Ser227
- 亚型
- IgG
- Top Product
- Discover our top product RPS6KA3 Primary Antibody
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anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) antibody
RPS6KA3 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4E10 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 1-740) antibodyRPS6KA3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 2-95) antibodyRPS6KA3 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2G10 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (Center) antibodyRPS6KA3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pThr573) antibodyRPS6KA3 适用: 人, 小鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pTyr529) antibodyRPS6KA3 适用: 人, 小鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 214-431) antibodyRPS6KA3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) antibodyRPS6KA3 适用: 人, 小鼠, 猴 WB, IP 宿主: 小鼠 Monoclonal 6B9-D6-F8 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pThr573) antibodyRPS6KA3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 342-376), (Ser369) antibodyRPS6KA3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB58150 unconjugated
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))
- 别名
- RSK2 (RPS6KA3 产品)
- 别名
- HU-1 antibody, MAPKAPK1A antibody, RSK antibody, RSK1 antibody, CLS antibody, HU-3 antibody, ISPK-1 antibody, MAPKAPK1B antibody, MRX19 antibody, RSK2 antibody, S6K-alpha3 antibody, p90-RSK2 antibody, pp90RSK2 antibody, MPK-9 antibody, Rsk2 antibody, RGD1563860 antibody, id:ibd1103 antibody, rps6ka3 antibody, si:ch211-114c12.12 antibody, wu:fk86e02 antibody, zgc:56006 antibody, zgc:158386 antibody, ribosomal protein S6 kinase A1 antibody, ribosomal protein S6 kinase A3 antibody, ribosomal protein S6 kinase polypeptide 3 antibody, ribosomal protein S6 kinase a, polypeptide 3a antibody, ribosomal protein S6 kinase, polypeptide 3b antibody, RPS6KA1 antibody, RPS6KA3 antibody, Rps6ka3 antibody, rps6ka3a antibody, rps6ka3b antibody
- 背景
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Synonyms: Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2, RPS6KA3, ISPK1, MAPKAPK1B, RSK2
Background: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).
- 基因ID
- 6197
- UniProt
- P51812
- 途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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