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c-MET 抗体 (pTyr1234, pTyr1235)

Name: c-MET 抗体 (pTyr1234, pTyr1235)
SKU: ABIN743843
Availability: OutOfStock

MET 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Image was kindly submitted by An anonymous end user. (c-MET 抗体 (pTyr1234, pTyr1235))

Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-Phospho-Met(Tyr1234/1235) Polyclonal Antibody, Unconjugated (ABIN743843) at 1:200 followed by conjugation to the secondary antibody and DAB staining (c-MET 抗体 (pTyr1234, pTyr1235))

IHC

2 images

产品编号 ABIN743843

发货至: 中国

Datasheet as PDF

抗原 See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))
抗原表位
41

28

28

27

12

11

9

7

7

7

6

5

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1234, pTyr1235
适用
232

133

102

6

6

5

4

4

2

2

2

1

1

1

1
人, 小鼠
宿主
203

39

3

2
兔
Compatible Secondaries
克隆类型
196

51
多克隆
标记
130

19

11

11

7

7

7

7

7

7

6

6

2

2

2

2

2

2

2

2

2

2

2
This c-MET antibody is un-conjugated
应用范围
163

104

44

31

26

20

14

13

13

9

8

4

4

4

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

特异性

These phosphorylation sites are homologous to Tyr1232 + Ty1233 in Mouse and Tyr1235 + Tyr1236 in Rat. Due to the highly conserved nature of this domain, there is a chance that this antibody will react with MSP receptors in Mouse and, less likely, in Human when phosphorylated at the the sites of Ser1238 and Ser1239 in Human, Ser1215 and Ser1216 in Mouse. No phosphorylation information is currently available Rat.

交叉反应

人, 小鼠

预测反应

Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human c-Met around the phosphorylation site of Tyr1234/1235

亚型

IgG

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MET 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

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MET 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

c-Met + (MET 产品)

别名

AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

背景

Synonyms: HGFR, AUTS9, RCCP2, c-Met, Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met, MET
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

基因ID

4233

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor