LYN 抗体 (pTyr508)
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- 抗原 See all LYN 抗体
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
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抗原表位
- pTyr508
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适用
- 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 犬, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LYN antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- Cow, 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human Lyn around the phosphorylation site of Tyr508
- 亚型
- IgG
- Top Product
- Discover our top product LYN Primary Antibody
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- 应用备注
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WB(1:100-500)
Optimal working dilution should be determined by the investigator. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
- 别名
- Lyn (LYN 产品)
- 别名
- JTK8 antibody, p53Lyn antibody, p56Lyn antibody, lyn antibody, LYN antibody, AA407514 antibody, Hck-2 antibody, jtk8 antibody, lyn-A antibody, CH73-38P6.3 antibody, zgc:92124 antibody, LYN proto-oncogene, Src family tyrosine kinase antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antibody, tyrosine-protein kinase Lyn antibody, LYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, LYN antibody, lyn antibody, Lyn antibody, LOC100593961 antibody, lyn.L antibody
- 背景
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Synonyms: Lyn phospho Y508, Lyn phospho Tyr508, p-Lyn Tyr508, Hck 2, JTK 8, JTK8, ONCOGENE LYN, Tyrosine protein kinase LYN, V yes 1 Yamaguchi sarcoma viral related oncogene homolog, Yamaguchi sarcoma viral v yes 1 related oncogene homolog, AA407514, EC 2.7.10.2, FLJ26625, LYN_HUMAN.
Background: Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.
- 分子量
- 57kDa
- 基因ID
- 4067
- 途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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