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CD163 抗体 (AA 1001-1121) (FITC)

CD163 适用: 人, 小鼠, 大鼠, Pig, 犬 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal FITC
产品编号 ABIN741577
发货至: 中国
  • 抗原 See all CD163 抗体
    CD163
    抗原表位
    • 16
    • 15
    • 15
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1001-1121
    适用
    • 128
    • 46
    • 28
    • 27
    • 18
    • 5
    • 3
    • 1
    人, 小鼠, 大鼠, Pig, 犬
    宿主
    • 108
    • 45
    • 1
    克隆类型
    • 95
    • 58
    • 1
    多克隆
    标记
    • 52
    • 17
    • 12
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD163 antibody is conjugated to FITC
    应用范围
    • 106
    • 71
    • 51
    • 38
    • 26
    • 26
    • 25
    • 24
    • 22
    • 20
    • 15
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    犬, 人, 小鼠, Pig, 大鼠
    预测反应
    Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human CD163/M130
    亚型
    IgG
    Top Product
    Discover our top product CD163 Primary Antibody
  • 应用备注
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Kobori, Hamasaki, Kitaura, Yamazaki, Nishinaka, Niwa, Nakao, Wake, Mori, Yoshino, Nishibori, Takahashi: "Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis." in: Frontiers in immunology, Vol. 9, pp. 334, (2019) (PubMed).

    Oh, Riek, Zhang, Williams, Darwech, Bernal-Mizrachi: "Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice." in: The Journal of steroid biochemistry and molecular biology, Vol. 177, pp. 179-186, (2017) (PubMed).

    Weng, Sprague, Oh, Riek, Chin, Garcia, Bernal-Mizrachi: "Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice." in: PLoS ONE, Vol. 8, Issue 1, pp. e54625, (2013) (PubMed).

  • 抗原
    CD163
    别名
    Cd163/M130 (CD163 产品)
    别名
    DMBT1 antibody, CD163 antibody, CD163v2 antibody, CD163v3 antibody, M130 antibody, MM130 antibody, deleted in malignant brain tumors 1 protein-like antibody, CD163 molecule antibody, CD163 antigen antibody, LOC426820 antibody, CD163 antibody, Cd163 antibody
    背景

    Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

    Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

    基因ID
    9332
    UniProt
    Q86VB7
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