Axin 抗体 (AA 761-862)
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- 抗原 See all Axin (AXIN1) 抗体
- Axin (AXIN1) (Axin 1 (AXIN1))
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抗原表位
- AA 761-862
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Axin antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Dog,Cow,Sheep,Pig,Guinea Pig
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Axin1
- 亚型
- IgG
- Top Product
- Discover our top product AXIN1 Primary Antibody
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anti-Axin 1 (AXIN1) (AA 546-752) antibody
AXIN1 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4E9F1 unconjugated
anti-Axin 1 (AXIN1) (AA 618-827) antibodyAXIN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 643-740) antibodyAXIN1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 488)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 488
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 594)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 594
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 390)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 390
anti-Axin 1 (AXIN1) (AA 470-570) antibody (FITC)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal FITC
anti-Axin 1 (AXIN1) (AA 470-570) antibody (APC)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal APC
anti-Axin 1 (AXIN1) (AA 546-752) antibodyAXIN1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4F10G1 unconjugated
anti-Axin 1 (AXIN1) (AA 653-862) antibodyAXIN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- Axin (AXIN1) (Axin 1 (AXIN1))
- 别名
- Axin1 (AXIN1 产品)
- 别名
- AXIN1 antibody, axin antibody, fused antibody, xAxin antibody, LOC100226467 antibody, AXIN antibody, PPP1R49 antibody, AI316800 antibody, Axin antibody, Fu antibody, Kb antibody, Ki antibody, kinky antibody, knobbly antibody, AXIN1-RGS antibody, wu:fi22e03 antibody, wu:fj14c08 antibody, wu:fk11b03 antibody, zgc:109872 antibody, axin 1 antibody, axin 1 S homeolog antibody, axin 1 L homeolog antibody, AXIN1 antibody, axin1.S antibody, axin1.L antibody, Axin1 antibody, axin1 antibody
- 背景
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Synonyms: AXIN, PPP1R49, Axin-1, Axis inhibition protein 1, hAxin, AXIN1
Background: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
- 基因ID
- 8312
- UniProt
- O15169
- 途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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