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TLR4 抗体 (AA 751-835)

Name: TLR4 抗体 (AA 751-835)
SKU: ABIN736491
Availability: OutOfStock

TLR4 适用: 人, 小鼠, 大鼠, Cow WB, FACS, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Mouse macrophages(RAW264. (TLR4 抗体 (AA 751-835))

IHC

Mouse splenocytes probed with Rabbit Anti-TLR4 Polyclonal Antibody . (TLR4 抗体 (AA 751-835))

FACS

IF (cc)

Image submitted by One World Lab validation program. (TLR4 抗体 (AA 751-835))

8 images

(13 references)

产品编号 ABIN736491

发货至: 中国

Datasheet as PDF

抗原 See all TLR4 抗体

TLR4 (Toll-Like Receptor 4 (TLR4))
抗原表位
16

16

16

15

8

7

7

5

4

4

4

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 751-835
适用
178

89

71

36

23

20

19

19

5

2

1

1
人, 小鼠, 大鼠, Cow
宿主
129

71

9

4
兔
Compatible Secondaries
克隆类型
133

80
多克隆
标记
90

20

20

16

7

6

3

3

3

3

3

3

3

3

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This TLR4 antibody is un-conjugated
应用范围
147

128

50

44

33

28

26

25

25

24

14

8

7

7

5

5

4

2

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

Cow, 人, 小鼠, 大鼠

预测反应

Dog,Sheep,Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from rat TLR4

亚型

IgG
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Toll-Like Receptor 4 (TLR4) (AA 49-247) antibody
TLR4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (HRP)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal HRP

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (FITC)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal FITC

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Alkaline Phosphatase (AP))
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Alkaline Phosphatase (AP)

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Biotin)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (PE)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal PE

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (APC)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal APC

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (PerCP)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal PerCP

anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Atto 488)
TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Kulhankova, Kinney, Stach, Gourronc, Grumbach, Klingelhutz, Salgado-Pabón: "The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function." in: Infection and immunity, (2018) (PubMed).

Xu, Zheng, Liu, Li, Yang, Shang: "Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 6, pp. 2091-2104, (2018) (PubMed).

Harasymowicz, Clement, Azfer, Burnett, Salter, Simpson: "Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients With Osteoarthritis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 69, Issue 7, pp. 1396-1406, (2017) (PubMed).

Wang, Li, Liu, Wang, Cao: "Inhibitory effect of Zanthoxylum bungeanum seed oil on ovalbumin‑induced lung inflammation in a murine model of asthma." in: Molecular medicine reports, Vol. 13, Issue 5, pp. 4289-302, (2017) (PubMed).

Arfian, Muflikhah, Soeyono, Sari, Tranggono, Anggorowati, Romi: "Vitamin D Attenuates Kidney Fibrosis via Reducing Fibroblast Expansion, Inflammation, and Epithelial Cell Apoptosis." in: The Kobe journal of medical sciences, Vol. 62, Issue 2, pp. E38-44, (2016) (PubMed).

Kawakita, Fujimoto, Liu, Nakano, Nakatsuka, Suzuki: "Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice." in: Molecular neurobiology, (2016) (PubMed).

Wang, Shi, Lv, Xu, Li, Ge, Xiao, Geng, Liu: "Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-?B Activation in Microglial Cells." in: Inflammation, (2015) (PubMed).

Namisaki, Noguchi, Moriya, Kitade, Aihara, Douhara, Nishimura, Takeda, Okura, Kawaratani, Takaya, Seki, Yoshiji: "Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis." in: Journal of gastroenterology, (2015) (PubMed).

Yang, Wang, Zhang, Yang, Lu, Zhang, Li, Zhang, Li: "Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-?B signaling pathway in isoproterenol-induced myocardial hypertrophy." in: Journal of ethnopharmacology, Vol. 150, Issue 3, pp. 1062-70, (2014) (PubMed).

Chen, Yu, Fan, Bian, Ma, Lu, Jin: "Sargassum fusiforme polysaccharide activates nuclear factor kappa-B (NF-?B) and induces cytokine production via Toll-like receptors." in: Carbohydrate polymers, Vol. 105, pp. 113-20, (2014) (PubMed).

Xing, Zheng, Zhang, Wang, Xing: "Relationship between toll-like receptor 4 levels in aorta and severity of atherosclerosis." in: The Journal of international medical research, Vol. 42, Issue 4, pp. 958-965, (2014) (PubMed).

Takanashi, Tomosada, Villena, Murata, Takahashi, Chiba, Tohno, Shimazu, Aso, Suda, Ikegami, Itoh, Kawai, Saito, Alvarez, Kitazawa: "Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation." in: BMC microbiology, Vol. 13, pp. 54, (2013) (PubMed).

Tang, Zhou, Wang, Zhang, Wang, Li, Huang: "Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts." in: Archives of oral biology, Vol. 56, Issue 10, pp. 1064-72, (2011) (PubMed).
抗原

TLR4 (Toll-Like Receptor 4 (TLR4))

别名

TLR4 (TLR4 产品)

别名

ARMD10 antibody, CD284 antibody, TLR-4 antibody, TOLL antibody, Lps antibody, Ly87 antibody, Ran/M1 antibody, Rasl2-8 antibody, toll like receptor 4 antibody, toll-like receptor 4 antibody, TLR4 antibody, Tlr4 antibody

背景

Synonyms: Lps, Ly87, Ran/M1, Rasl2-8, Toll-like receptor 4, CD284, Tlr4
Background: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

基因ID

21898

UniProt

Q9QX05

途径

TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins