TBPL1 抗体 (AA 301-400)
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- 抗原 See all TBPL1 抗体
- TBPL1 (TBP-Like 1 (TBPL1))
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抗原表位
- AA 301-400
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TBPL1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Dog,Pig,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TRF2
- 亚型
- IgG
- Top Product
- Discover our top product TBPL1 Primary Antibody
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anti-TBP-Like 1 (TBPL1) (AA 1-186) antibody
TBPL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (AA 88-137) antibodyTBPL1 适用: 人, 小鼠, 大鼠, 猴, 犬, 兔, Cow, 马, 豚鼠, Pig, Bat, 小鸡, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (AA 1-186) antibodyTBPL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) antibodyTBPL1 适用: 人 WB, ELISA, IHC, IP, FACS, ChIP, FM 宿主: 小鼠 Monoclonal 4A794-15 unconjugated
anti-TBP-Like 1 (TBPL1) (AA 1-185) antibodyTBPL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (C-Term) antibodyVerified TBPL1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (Middle Region) antibodyTBPL1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- TBPL1 (TBP-Like 1 (TBPL1))
- 别名
- TRF2 (TBPL1 产品)
- 别名
- MGC:8389 antibody, MGC:9620 antibody, STUD antibody, TLF antibody, TLP antibody, TRF2 antibody, tlf antibody, 4732475G08 antibody, AW011832 antibody, AW491032 antibody, D18347 antibody, STD antibody, TRP antibody, Tlp antibody, tlp antibody, trf antibody, trf2 antibody, trp antibody, zgc:92340 antibody, TATA binding protein 1 antibody, TFIID-1 antibody, TRANSCRIPTION FACTOR IID-1 antibody, TATA-box binding protein like 1 antibody, TATA-binding protein 1 antibody, TATA-box binding protein like 1 L homeolog antibody, TATA box binding protein-like 1 antibody, TBP-like 1 antibody, TATA binding protein 1 antibody, TBPL1 antibody, tbp1 antibody, tbpl1.L antibody, tbpl1 antibody, Tbpl1 antibody, TBP1 antibody
- 背景
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Synonyms: TRF2, TRBF2, Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, TERF2
Background: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
- 基因ID
- 7014
- UniProt
- Q15554
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