DTNBP1 抗体 (AA 101-200)
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- 抗原 See all DTNBP1 抗体
- DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
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抗原表位
- AA 101-200
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DTNBP1 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Cow,Sheep,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human DTNBP1
- 亚型
- IgG
- Top Product
- Discover our top product DTNBP1 Primary Antibody
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
- 别名
- DTNBP1 (DTNBP1 产品)
- 别名
- 5430437B18Rik antibody, AW048963 antibody, Bloc1s8 antibody, dysbindin antibody, sdy antibody, BLOC1S8 antibody, DBND antibody, HPS7 antibody, My031 antibody, SDY antibody, dtnbp1 antibody, zgc:56462 antibody, MGC83903 antibody, dbnd antibody, hps7 antibody, my031 antibody, MGC85477 antibody, DTNBP1 antibody, CG6856 antibody, Ddysb antibody, Dmel\\CG6856 antibody, si:ch211-285p6.1 antibody, dystrobrevin binding protein 1 antibody, Dysbindin antibody, dystrobrevin binding protein 1a antibody, dystrobrevin binding protein 1 L homeolog antibody, dystrobrevin binding protein 1 S homeolog antibody, dystrobrevin binding protein 1b antibody, Dtnbp1 antibody, DTNBP1 antibody, dtbp1 antibody, dtnbp1a antibody, dtnbp1.L antibody, dtnbp1.S antibody, dtnbp1 antibody, Dysb antibody, dtnbp1b antibody
- 背景
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Synonyms: SDY, DBND, HPS7, My031, BLOC1S8, Dysbindin, Biogenesis of lysosome-related organelles complex 1 subunit 8, BLOC-1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, HPS7 protein, DTNBP1
Background: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
- 基因ID
- 84062
- UniProt
- Q96EV8
- 途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling
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