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Fibulin 1 抗体 (AA 501-600)

FBLN1 适用: 人, 大鼠 WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN728458
发货至: 中国
  • 抗原 See all Fibulin 1 (FBLN1) 抗体
    Fibulin 1 (FBLN1)
    抗原表位
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 501-600
    适用
    • 46
    • 20
    • 16
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 51
    • 13
    • 1
    克隆类型
    • 53
    • 12
    多克隆
    标记
    • 31
    • 16
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Fibulin 1 antibody is un-conjugated
    应用范围
    • 55
    • 35
    • 25
    • 12
    • 9
    • 8
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    交叉反应
    人, 大鼠
    预测反应
    Mouse,Dog,Cow,Pig,Horse,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Fibulin 1
    亚型
    IgG
    Top Product
    Discover our top product FBLN1 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Angenendt, Reuter, Kentrup, Benk, Neumann, Hüve, Martens, Schwöppe, Kessler, Schmidt, Sauer, Brand, Mikesch, Lenz, Mesters, Müller-Tidow, Hartmann, Wardelmann, Neri, Berdel, Roesli, Schliemann: "An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia." in: Leukemia, Vol. 32, Issue 2, pp. 510-519, (2017) (PubMed).

  • 抗原
    Fibulin 1 (FBLN1)
    别名
    Fibulin 1 (FBLN1 产品)
    别名
    fbln1 antibody, FBLN antibody, FIBL1 antibody, fbln1c antibody, fbln1d antibody, wu:fc52c06 antibody, MGC115035 antibody, fibulin 1 antibody, fibulin 1 L homeolog antibody, FBLN1 antibody, fbln1 antibody, Fbln1 antibody, fbln1.L antibody, CpipJ_CPIJ017419 antibody
    背景

    Synonyms: Basement membrane protein 90, BM 90, FBLN, FBLN1, FIBL 1, FIBL1, Fibulin 1.

    Background: Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.

    基因ID
    2192
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