Recombinant RSV (Felvizumab Biosimilar) 抗体
适用: Respiratory Syncytial Virus (RSV)
ELISA, Func
宿主: 小鼠
Chimeric
RSHZ19
unconjugated
Recombinant Antibody
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- 抗原 See all RSV (Felvizumab Biosimilar) products
- RSV (Felvizumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- Respiratory Syncytial Virus (RSV)
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宿主
- 小鼠
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克隆类型
- Chimeric
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标记
- This RSV (Felvizumab Biosimilar) antibody is un-conjugated
- 应用范围
- ELISA, Functional Studies (Func)
- 原理
- Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a, kappa
- 特异性
- This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.
- 产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
- 克隆位点
- RSHZ19
- 亚型
- IgG2a kappa
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- 应用备注
- Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
- 说明
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- RSV (Felvizumab Biosimilar)
- Abstract
- RSV (Felvizumab Biosimilar) 产品
- 物质类
- Biosimilar
- 背景
- SB 209763, respiratory syncytial virus
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