Recombinant EGFR (Nimotuzumab Biosimilar) 抗体
适用: 人
BR, FACS, IHC
宿主: 小鼠
Chimeric
h-R3
unconjugated
Recombinant Antibody
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- 抗原 See all EGFR (Nimotuzumab Biosimilar) products
- EGFR (Nimotuzumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- Chimeric
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标记
- This EGFR (Nimotuzumab Biosimilar) antibody is un-conjugated
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应用范围
- Blocking Reagent (BR), Flow Cytometry (FACS), Immunohistochemistry (IHC)
- 原理
- Anti-EGFR domain III [h-R3 (Nimotuzumab)], Mouse IgG2a, kappa
- 特异性
- Binds to human EGFR domain III at a site distinct from antibody 7A7 (Ab00134) (Talavera et al. 2011)
- 产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody we generated by humanisation of the murine antibody R3, raised against EGFR purified from placenta membranes and A431 tumors.
- 克隆位点
- H-R3
- 亚型
- IgG2a kappa
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- 应用备注
- This antibody binds to human EGFR and inhibits EGF-dependent clonogenic growth of NRK cells and completely blocks EGF stimulated autophosphorylation of the receptor (Fernandez 1992)
- 说明
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- EGFR (Nimotuzumab Biosimilar)
- Abstract
- EGFR (Nimotuzumab Biosimilar) 产品
- 物质类
- Biosimilar
- 背景
- ERBB-D3, ERBB1, HER1, PIG61, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, epidermal growth factor
- UniProt
- P00533
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