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Recombinant TNF alpha (Adalimumab Biosimilar) 抗体

适用: 人 ELISA, BR, IF, IHC 宿主: 小鼠 Chimeric D2E7 unconjugated Recombinant Antibody
产品编号 ABIN7543059
发货至: 中国
  • 抗原 See all TNF alpha (Adalimumab Biosimilar) products
    TNF alpha (Adalimumab Biosimilar)
    抗体类型
    Recombinant Antibody
    适用
    宿主
    • 2
    • 1
    • 1
    • 1
    小鼠
    克隆类型
    • 4
    • 1
    Chimeric
    标记
    • 5
    This TNF alpha (Adalimumab Biosimilar) antibody is un-conjugated
    应用范围
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)
    原理
    Anti-TNF alpha [D2E7 (Adalimumab)], Mouse IgG2a, kappa
    特异性
    Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
    交叉反应
    小鼠
    产品特性

    Original Species of Ab: Human

    Original Format of Ab: IgG1

    纯化方法
    Protein A affinity purified
    免疫原
    This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
    克隆位点
    D2E7
    亚型
    IgG2a kappa
  • 应用备注
    Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).
    说明

    This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % Proclin 300.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原
    TNF alpha (Adalimumab Biosimilar)
    Abstract
    TNF alpha (Adalimumab Biosimilar) 产品
    物质类
    Biosimilar
    背景
    Tumor necrosis factor alpha
    UniProt
    P01375
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