EBV LMP1 抗体
-
- 抗原 See all EBV LMP1 products
- EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))
- 适用
- Epstein-Barr Virus (EBV)
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This EBV LMP1 antibody is un-conjugated
-
应用范围
- Immunohistochemistry (IHC)
- Supplier Product No.
- mob194-01
- Supplier
- Rockland
- 原理
- LMP-1 (Epstein-Barr Virus) Monoclonal Antibody
- 交叉反应 （详细）
- This antibody is specific to 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV.
- 纯化方法
- The antibody was clarified from tissue culture supernatant.
- 免疫原
- Anti-LMP-1 (Epstein-Barr Virus) antibody was produced in mice by repeated immunizations with recombinant fusion protein containing sequences of bacterial beta-galactosidase and EBV encoded latent membrane protein.
- 克隆位点
- CS1-CS2-CS3-CS4
- 亚型
- IgG1
-
anti-Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1) antibody
EBV LMP1 适用: Epstein-Barr Virus (EBV) WB, IF, IHC, StM 宿主: 小鼠 Monoclonal CS4 unconjugated
anti-Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1) antibodyEBV LMP1 适用: Epstein-Barr Virus (EBV) WB, Coat, ELISA 宿主: 小鼠 Monoclonal CS1 unconjugated
-
- 应用备注
- Optional[Neutralization_Dilution]: 1:50-1:100
- 说明
-
Anti-LMP-1 (Epstein-Barr Virus) (MOUSE) Monoclonal Antibody was tested in IHC-P with positive control infected lymphoblastoma, Hodgkin's lymphoma tissues. Cellular Localization: Cytoplasmic. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Preservative: 0.01 % (w/v) Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. This antibody is suitable for use until the expiration date when stored at 2-8°C. Do not use product after the expiration date printed on vial. If reagents are stored under conditions other than those specified here, they must be verified by the user. Diluted reagents should be used promptly. Unused portions of antibody preparation should be discarded after one day. The presence of precipitate or an unusual odor indicates that the antibody is deteriorating and should not be used.
-
- 抗原
- EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))
- 别名
- EBV LMP-1 (EBV LMP1 产品)
- 物质类
- Viral Protein
- 背景
- Epstein-Barr Virus, EBV, Latent Membrane Protein 1, Human herpesvirus 4, HHV-4,Latent membrane protein 1 acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. It functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, LMP1 induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.
-
