FcRn 抗体
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- Key Features
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- High-quality FcRn antibody (Clone ADM31) for the detection of FcRn.
- Highly specific for human FcRn, blocks the binding of human serum albumin.
- contains Glycerol for better storage.
- 抗原 See all FcRn 抗体
- FcRn (IgG receptor FcRn (FcRn))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FcRn antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA), Functional Studies (Func)
- 产品特性
- based on recognition of the complete native protein expressed on transfected mammalian cells
- 纯化方法
- Purified, Protein G
- 免疫原
- hFcRn
- 克隆位点
- ADM31
- 亚型
- IgG2b lambda
- Top Product
- Discover our top product FcRn Primary Antibody
- Product Specific Information
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What can the FcRn antibody ABIN7539617 / ADM31 antibody be used for? This monoclonal mouse anti-FcRn antibody is unconjugated and is suitable for the detection of FcRn (Fc receptor) in human samples. The FcRn antibody is validated for Cell ELISA, ELISA, FACS and IF.
What validation data is available for this FcRn antibody / ADM31 antibody? 6 images for FACS and other applications are available. The product is cited in 15 PubMed publications. User our high quality product to reliably detect Fc receptor.
The MHC class I-like Fc receptor (FcRn) functions as an intracellular trafficking receptor, uniquely accountable for prolonging the serum half-life of IgG subclass antibodies and facilitating their passage across cellular barriers. Through these actions, FcRn significantly impacts various aspects of antibody biology and pathobiology. Its crucial role in regulating IgG pharmacokinetics has been exploited in the development of therapeutic antibodies and related biological treatments. Additionally, FcRn is involved in the transport of serum albumin, contributing to the improved pharmacokinetic characteristics of albumin-conjugated therapies. However, a lack of dependable serological tools targeting human FcRn has limited the comprehension of its functions and potential therapeutic uses.
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anti-IgG receptor FcRn (FcRn) antibody
FcRn 适用: 人 ELISA, IF, FACS, cELISA, Func 宿主: 小鼠 Monoclonal ADM31 unconjugated
anti-IgG receptor FcRn (FcRn) antibodyFcRn 适用: 人 ELISA, IF, FACS, cELISA 宿主: 小鼠 Monoclonal DVN24 unconjugated
anti-IgG receptor FcRn (FcRn) antibodyFcRn 适用: 人 ELISA, IF, FACS, cELISA 宿主: 小鼠 Monoclonal DVN24 unconjugated
anti-IgG receptor FcRn (FcRn) (AA 24-297) antibodyFcRn 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-IgG receptor FcRn (FcRn) (AA 24-365) antibodyFcRn 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-IgG receptor FcRn (FcRn) (AA 24-215) antibodyFcRn 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal FCGRT-2932 unconjugated
anti-IgG receptor FcRn (FcRn) (AA 24-297) antibodyFcRn 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2B3B11 unconjugated
anti-IgG receptor FcRn (FcRn) (AA 24-297) antibodyFcRn 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5F3D1 unconjugated
anti-IgG receptor FcRn (FcRn) (AA 25-300) antibodyFcRn 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-IgG receptor FcRn (FcRn) (N-Term) antibodyFcRn 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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- Flow cytometry: 1.2 μg/10^6 cells
- ELISA: 1:200 - 1:400
- CELISA: 1:200 - 1:400
- 限制
- 仅限研究用
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- 缓冲液
- PBS pH 7.2 with 50% glycerol
- 注意事项
- avoid repeated freezing and thawing
- 储存条件
- 4 °C
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- 抗原
- FcRn (IgG receptor FcRn (FcRn))
- 别名
- Fc Receptor (FcRn) FcRn (FcRn 产品)
- 别名
- FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody
- 背景
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The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT - UniProt
- P55899
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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