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DNAJB9 抗体

DNAJB9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7539265
发货至: 中国
  • 抗原 See all DNAJB9 抗体
    DNAJB9 (Microvascular Endothelial Differentiation Gene 1 Protein (DNAJB9))
    适用
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    宿主
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    克隆类型
    • 30
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    多克隆
    标记
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    This DNAJB9 antibody is un-conjugated
    应用范围
    • 21
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    Western Blotting (WB)
    原理
    Mdg-1 antibody
    纯化方法
    Protein-A purified
    免疫原
    Recombinant human Mdg-1
    Top Product
    Discover our top product DNAJB9 Primary Antibody
  • 应用备注
    Western Blot: Use 1-5 μg/mL
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
    缓冲液
    PBS
    储存条件
    4 °C,-20 °C
    储存方法
    The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
    有效期
    24 months
  • 抗原
    DNAJB9 (Microvascular Endothelial Differentiation Gene 1 Protein (DNAJB9))
    别名
    Mdg-1 (DNAJB9 产品)
    别名
    ERdj4 antibody, MDG-1 antibody, MDG1 antibody, MST049 antibody, MSTP049 antibody, AA408011 antibody, AA673251 antibody, AA673481 antibody, AW556981 antibody, Mdg1 antibody, mDj7 antibody, DnaJ heat shock protein family (Hsp40) member B9 antibody, DNAJB9 antibody, Dnajb9 antibody
    背景
    Microvascular endothelial differentiation gene 1 protein, DnaJ homolog subfamily B member 9, ERdj4,Angiogenesis research has focused on receptors and ligands mediating endothelial cell proliferation and migration. Little is known about the molecular mechanisms that are involved in converting endothelial cells from a proliferative to a differentiated state. Microvascular differentiation gene 1 (Mdg1) has been isolated from differentiating microvascular endothelial cells that had been cultured in collagen type I gels (3D culture). In adult human tissue Mdg1 is expressed in endothelial and epithelial cells. Sequence analysis of the full-length cDNA revealed that the N-terminal region of the putative Mdg1-protein exhibits a high sequence similarity to the J-domain of Hsp40 chaperones. It was shown that this region functions as a bona fide J-domain as it can replace the J-domain of Escherichia coli DnaJ-protein. Mdg1 is also upregulated in primary endothelial and mesangial cells when subjected to various stress stimuli. GFP-Mdg1 fusion constructs showed the Mdg1-protein to be localized within the cytoplasm under control conditions. Stress induces the translocation of Mdg1 into the nucleus, where it accumulates in nucleoli. Costaining with Hdj1, Hdj2, Hsp70, and Hsc70 revealed that Mdg1 colocalizes with Hsp70 and Hdj1 in control and stressed HeLa cells. These data suggest that Mdg1 is involved in the control of cell cycle arrest taking place during terminal cell differentiation and under stress conditions.
    基因ID
    4189
    NCBI登录号
    NM_012328, NP_036460
    UniProt
    Q9UBS3
    途径
    ER-Nucleus Signaling
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