The mouse monoclonal antibody A1 recognizes an epitope within extracellular domain of CD307d, a transmembrane glycoprotein expressed mainly on memory B cells.
纯化方法
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
免疫原
DNA-immunization followed by a boost with CD307d-transfected cells
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
CD307d antibody, FCRH4 antibody, IGFP2 antibody, IRTA1 antibody, FCRL4 antibody, Fc receptor like 4 antibody, Fc receptor-like 4 antibody, Fc receptor-like 4 L homeolog antibody, FCRL4 antibody, fcrl4 antibody, fcrl4.L antibody
背景
Fc receptor like 4,CD307d is a type I transmembrane glycoprotein of the Fc receptor family. It contains two ITIM motifs and one ITSM motif in its cytoplasmic domain. CD307d is expressed mainly on the surface of memory B cells in mucosa-associated lymphoid tissues. It binds to aggregated immunoglobulin molecules (IgA, IgG). Defects of CD307d may play a role in HIV-induced memory B cell dysfunction.,FcRL4, FCRH4, IRTA1