The mouse monoclonal antibody 9E8 recognizes an extracellular epitope of human CD367, a type II transmembrane protein of C-lectin family, expressed mainly on antigen presenting cells.
纯化方法
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
CLEC4A antibody, CLECSF6 antibody, DCIR antibody, DDB27 antibody, LLIR antibody, Clecsf6 antibody, Dcir1 antibody, Clec4a antibody, zinc finger protein 705A antibody, C-type lectin domain family 4 member A antibody, C-type lectin domain family 4, member A antibody, C-type lectin domain family 4, member a2 antibody, ZNF705A antibody, CLEC4A antibody, Clec4a antibody, Clec4a2 antibody
背景
C-type lectin domain family 4 member A,CD367 is an approximately 20-28 kDa C-type lectin with immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic part. CD367 binds in calcium-dependent manner to mannose, fucose, and weakly also to N-acetylglucosamine. It is expressed on dendritic cells, macrophages, monocytes, B cells, and neutrophils. In rheumatoid arthitis patients CD367 is expressed also on CD4+ T cells. After ligand-mediated triggering, it is internalized by clathrin-dependent endocytosis and contributes to the antigen presentation to CD8+ T cells. It may also be involved in modulation of the antigen presenting cell response.,DCIR, CLEC4A, LLIR