The mouse monoclonal antibody H5 recognizes an epitope within extracellular part of CD307c, a transmembrane glycoprotein expressed mainly on NK cells, and T and B cell subsets.
纯化方法
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
免疫原
DNA-immunization followed by a boost with CD307c transfected cells
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
CD307c antibody, FCRH3 antibody, IFGP3 antibody, IRTA3 antibody, SPAP2 antibody, fcrh3 antibody, ifgp3 antibody, irta3 antibody, spap2 antibody, xfl1.2 antibody, Fc receptor like 3 antibody, Fc receptor-like 3 L homeolog antibody, Fc receptor-like 3 antibody, Fc receptor-like 3 S homeolog antibody, FCRL3 antibody, fcrl3.L antibody, fcrl3 antibody, fcrl3.S antibody
背景
Fc receptor like 3,CD307c is a type I transmembrane glycoprotein of the Fc receptor family. It contains both ITAM and ITIM motifs in its cytoplasmic domain. CD307c is expressed on the surface of NK cells, and T, Treg, B and plasma cell subsets. It seems to play a role in the regulation of immune response. Defects in CD307c function can result in autoimmune diseases, e.g. rheumatoid arthritis or systemic lupus erythematosus.,FcRL3, IRTA3