Thrombomodulin 抗体
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- 抗原 See all Thrombomodulin (THBD) 抗体
- Thrombomodulin (THBD)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Thrombomodulin antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 原理
- Anti-Hu CD141 Purified
- 特异性
- The mouse monoclonal antibody M80 recognizes an extracellular epitope of CD141, a 75 kDa transmembrane glycoprotein expressed mainly on macrophages, monocytes, platelets and endothelial cells.
- 纯化方法
- Purified by protein-A affinity chromatography.
- 免疫原
- MV4-11 cell line
- 克隆位点
- M80
- 亚型
- IgG1
- Top Product
- Discover our top product THBD Primary Antibody
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- 应用备注
- Flow cytometry: Recommended dilution: 1-5 μg/mL
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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- 抗原
- Thrombomodulin (THBD)
- 别名
- CD141 (THBD 产品)
- 别名
- AHUS6 antibody, BDCA3 antibody, CD141 antibody, THPH12 antibody, THRM antibody, TM antibody, AI385582 antibody, THBD antibody, HAST antibody, HAST3 antibody, M-PST antibody, ST1A3/ST1A4 antibody, ST1A5 antibody, STM antibody, TL-PST antibody, thrombomodulin antibody, sulfotransferase family 1A member 3 antibody, THBD antibody, Thbd antibody, SULT1A3 antibody
- 背景
- Thrombomodulin,CD141, also known as thrombomodulin or fetomodulin, is a single chain type I transmembrane glycoprotein serving as a receptor for thrombin and as an important cofactor in the protein C anticoagulant system, but it is also involved in embryonic and atherosclerotic plaque development. CD141 is expressed mainly on macrophages, monocytes, a subpopulation of myeloid dendritic cells, on platelets and endothelial cells, but also e.g. on keratinocytes (epithelium). After binding to thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. Mutations in the CD141 gene can cause a thromboembolic disease known as inherited thrombophilia.,Thrombomodulin, fetomodulin, THBD, THRM, THPH12, TM
- 基因ID
- 7056
- UniProt
- P07204
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