Recombinant TNFSF13B (Tabalumab Biosimilar) 抗体 (AA 133-285)
适用: 人
ELISA, WB, IF, IP, Neut, FACS, Func
宿主: 兔
Chimeric
unconjugated
Recombinant Antibody
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- 抗原 See all TNFSF13B (Tabalumab Biosimilar) products
- TNFSF13B (Tabalumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 抗原表位
- AA 133-285
- 适用
- 人
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宿主
- 兔
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克隆类型
- Chimeric
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标记
- This TNFSF13B (Tabalumab Biosimilar) antibody is un-conjugated
- 应用范围
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Neutralization (Neut), Flow Cytometry (FACS), Functional Studies (Func)
- 特异性
- Tabalumab neutralises soluble and membrane-bound BAFF, inhibiting BAFF binding to BR3, TACI and BCMA.
- 交叉反应
- Cynomolgus, 兔
- 产品特性
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OriginalSpeciesName: Human
OriginalFormat: IgG4
- 纯化方法
- Purified antibody.
- 免疫原
- Monoclonal antibodies were generated by immunizing human immunoglobulin transgenic mice with soluble human BAFF (amino acids 133-285). Eight mice producing serum antibody titers to human BAFF were injected intravenously with 10 mug human BAFF in phosphate buffered saline. The spleen was harvested 3 days later from each mouse and fused with myeloma cells. 20 Hybridomas were tested for specific binding to human BAFF and to make sure they were expressing human immunoglobulin heavy and light chains by enzyme-linked immunosorbent assay (ELISA). The hybridoma producing the antibody that eventually became tabalumab was a human IgG1 isotype. The antibody was then engineered to a human IgG4 isotype for complete neutralization of BAFF without depletion of BAFF-expressing cells.
- 亚型
- IgG kappa
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- TNFSF13B (Tabalumab Biosimilar)
- Abstract
- TNFSF13B (Tabalumab Biosimilar) 产品
- 别名
- BAFF antibody, BLYS antibody, CD257 antibody, DTL antibody, TALL-1 antibody, TALL1 antibody, THANK antibody, TNFSF20 antibody, ZTNF4 antibody, TNF superfamily member 13b antibody, TNFSF13B antibody
- 背景
- TNFSF20, B-cell activating factor, Tumor Necrosis Factor Superfamily Member 13b, BAFF, Tumor Necrosis Factor (Ligand) Superfamily, Member 13b, Dendritic Cell-Derived TNF-Like Molecule, TALL-1, TALL1, ZTNF4, BLYS, Tumor Necrosis Factor (Ligand) Superfamily, Member 20, Tumor Necrosis Factor Ligand Superfamily Member 13B, TNF- And APOL-Related Leukocyte Expressed Ligand 1, TNF And ApoL-Related Leukocyte Expressed Ligand 1, Tumor Necrosis Factor-Like Protein ZTNF4, TNF Homolog That Activates Apoptosis, Tumor Necrosis Factor Ligand 7A, ApoL Related Ligand TALL-1, B-Lymphocyte Stimulator, B Lymphocyte Stimulator, CD257 Antigen, Delta4 BAFF, Delta BAFF, TNLG7A, THANK, DTL, LY 2127399, LY2127399
- UniProt
- Q9Y275
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