RAB7A 抗体 (AA 101-207)
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- 抗原 See all RAB7A 抗体
- RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))
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抗原表位
- AA 101-207
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RAB7A antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human RAB7
- 亚型
- IgG
- Top Product
- Discover our top product RAB7A Primary Antibody
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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Intracellular pathways following uptake of bevacizumab in RPE cells." in: Experimental eye research, Vol. 131, pp. 29-41, (2015) (PubMed).
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Intracellular pathways following uptake of bevacizumab in RPE cells." in: Experimental eye research, Vol. 131, pp. 29-41, (2015) (PubMed).
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- 抗原
- RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))
- 别名
- RAB7 (RAB7A 产品)
- 别名
- RAB5 antibody, PRO2706 antibody, RAB7 antibody, Rab7 antibody, rab7 antibody, pro2706 antibody, RAB7A antibody, LOC100231734 antibody, ARABIDOPSIS RAB GTPASE HOMOLOG G2 antibody, ATRAB7A antibody, ATRABG2 antibody, F7D8.20 antibody, F7D8_20 antibody, RAB GTPase homolog 7A antibody, DDBDRAFT_0190210 antibody, DDBDRAFT_0191507 antibody, DDB_0190210 antibody, DDB_0191507 antibody, Rab7a antibody, rab-7 antibody, zgc:64058 antibody, RAB5A, member RAS oncogene family antibody, RAB7A, member RAS oncogene family antibody, RAB7A, member RAS oncogene family L homeolog antibody, rab7A protein antibody, RAB GTPase homolog 7A antibody, Rab GTPase antibody, ras-related protein rab-7a antibody, RAB7, member RAS oncogene family antibody, RAB5A antibody, RAB7A antibody, Rab7a antibody, rab7a.L antibody, rab7a antibody, rab7A antibody, Rab7 antibody, rab7 antibody
- 背景
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Synonyms: RAB7, PRO276, Ras-related protein Rab-7a, RAB7A
Background: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.
- 基因ID
- 7879
- UniProt
- P51149
- 途径
- EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome
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