ASXL1 抗体 (N-Term)
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- 抗原 See all ASXL1 抗体
- ASXL1 (Additional Sex Combs Like 1 (ASXL1))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ASXL1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Knockdown/Knockout validation was supported by references (PMID:26385183)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Purified by antigen-affinity chromatography.
- 质量等级
- KO Validated
- 免疫原
- Recombinant protein encompassing a sequence within the N-terminus region of human ASXL1. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product ASXL1 Primary Antibody
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anti-Additional Sex Combs Like 1 (ASXL1) (AA 1-84) antibody
ASXL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6E2 unconjugated
anti-Additional Sex Combs Like 1 (ASXL1) (AA 521-549) antibodyASXL1 适用: 小鼠 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB24070 unconjugated
anti-Additional Sex Combs Like 1 (ASXL1) (AA 521-549) antibodyASXL1 适用: 人, 小鼠 WB, FACS, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Additional Sex Combs Like 1 (ASXL1) antibodyASXL1 适用: 人 DB 宿主: 小鼠 Monoclonal 2049C2a unconjugated
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- 应用备注
- WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: GFP-human ASXL1-transfected 293T cells Validation: KO/KD, Overexpression
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- ASXL1 (Additional Sex Combs Like 1 (ASXL1))
- 别名
- ASXL1 (ASXL1 产品)
- 别名
- asxl1 antibody, MGC83850 antibody, mKIAA0978 antibody, BOPS antibody, MDS antibody, additional sex combs like 1, transcriptional regulator L homeolog antibody, additional sex combs like 1, transcriptional regulator antibody, additional sex combs like 1 antibody, asxl1.L antibody, ASXL1 antibody, asxl1 antibody, Asxl1 antibody
- 背景
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Synonyms: ASXL transcriptional regulator 1 , BOPS , MDS
Background: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- 分子量
- 165 kDa
- 基因ID
- 171023
- UniProt
- Q8IXJ9
- 途径
- Retinoic Acid Receptor Signaling Pathway
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