PHAX 抗体
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- 抗原 See all PHAX 抗体
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PHAX antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人
- 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human PHAX. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product PHAX Primary Antibody
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anti-phosphorylated Adaptor For RNA Export (PHAX) (AA 6-243) antibody
PHAX 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphorylated Adaptor For RNA Export (PHAX) (AA 297-326), (C-Term) antibodyPHAX 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32550 unconjugated
anti-phosphorylated Adaptor For RNA Export (PHAX) (AA 304-334), (C-Term) antibodyPHAX 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: 293T
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
- 别名
- PHAX (PHAX 产品)
- 别名
- RNUXA antibody, 2810055C14Rik antibody, 4933427L19Rik antibody, AU018701 antibody, AU018854 antibody, D18Ertd65e antibody, Rnuxa antibody, p55 antibody, phosphorylated adaptor for RNA export antibody, PHAX antibody, Phax antibody
- 背景
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Synonyms: phosphorylated adaptor for RNA export , RNUXA
Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
- 分子量
- 44 kDa
- 基因ID
- 51808
- UniProt
- Q9H814
- 途径
- Ribonucleoprotein Complex Subunit Organization
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