LIN7B 抗体
Quick Overview for LIN7B 抗体 (ABIN7468551)
抗原
See all LIN7B 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human LIN7B. The exact sequence is proprietary.
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亚型
- IgG
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anti-Lin-7 Homolog B (LIN7B) (AA 35-62), (N-Term) antibody
LIN7B 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB40557 unconjugated
anti-Lin-7 Homolog B (LIN7B) (N-Term) antibodyVerified LIN7B 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 293T
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.69 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- LIN7B (Lin-7 Homolog B (LIN7B))
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别名
- lin-7 homolog B, crumbs cell polarity complex component
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背景
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Synonyms: lin-7 homolog B, crumbs cell polarity complex component , LIN-7B , MALS-2 , MALS2 , VELI2
Background: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
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分子量
- 23 kDa
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基因ID
- 64130
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UniProt
- Q9HAP6
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途径
- Synaptic Membrane
抗原
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