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ATR 抗体 (pThr1989)

ATR 适用: 人 WB, IP, ICC, IF 宿主: 小鼠 Monoclonal GT222 unconjugated
产品编号 ABIN7467984
发货至: 中国
  • 抗原 See all ATR 抗体
    ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
    抗原表位
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr1989
    适用
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 6
    • 1
    小鼠
    克隆类型
    • 6
    • 1
    单克隆
    标记
    • 7
    This ATR antibody is un-conjugated
    应用范围
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
    交叉反应
    纯化方法
    Affinity purified by Protein A.
    免疫原
    Carrier-protein conjugated synthetic peptide surrounding phospho Thr1989 of human ATR. The exact sequence is proprietary.
    克隆位点
    GT222
    亚型
    IgG2b
    Top Product
    Discover our top product ATR Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: HCT116 , HCT116(100 J/m2 UVC and recover for 6hr) Validation: Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    1XPBS ( pH 7), 20 % Glycerol, No Preservative
    储存液
    Without preservative
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
    别名
    ATR serine/threonine kinase (ATR 产品)
    别名
    ATR antibody, si:dkey-231j24.1 antibody, FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, XATR antibody, frp1 antibody, mec1 antibody, sckl antibody, sckl1 antibody, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED antibody, ATATR antibody, ATRAD3 antibody, Ataxia telangiectasia-mutated and RAD3-related antibody, MHK7.5 antibody, MHK7_5 antibody, ataxia telangiectasia and Rad3 related antibody, ATR serine/threonine kinase antibody, ATR serine/threonine kinase L homeolog antibody, Ataxia telangiectasia-mutated and RAD3-like protein antibody, Atr antibody, ATR antibody, atr antibody, atr.L antibody
    背景

    Synonyms: ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

    Background: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]

    分子量
    301 kDa
    基因ID
    545
    UniProt
    Q13535
    途径
    p53 Pathway, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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