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BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) 抗体

BABAM1 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal GT1251 unconjugated
产品编号 ABIN7467205
发货至: 中国
  • 抗原 See all BRISC and BRCA1 A Complex Member 1 (BABAM1) 抗体
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    抗原表位
    • 9
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    N-Term
    适用
    • 26
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    宿主
    • 22
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    小鼠
    克隆类型
    • 25
    • 1
    单克隆
    标记
    • 16
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    非结合性
    应用范围
    • 23
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    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    交叉反应
    纯化方法
    Affinity purified by Protein G.
    免疫原
    Recombinant protein encompassing a sequence within the N-terminus region of human HSPC142. The exact sequence is proprietary.
    克隆位点
    GT1251
    亚型
    IgG2a
    Top Product
    Discover our top product BABAM1 Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Validation: Overexpression

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS, No Preservative
    储存液
    Without preservative
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    别名
    BRISC and BRCA1 A complex member 1 (BABAM1 产品)
    别名
    merit40 antibody, nba1 antibody, zgc:100909 antibody, c19orf62 antibody, C19orf62 antibody, MERIT40 antibody, NBA1 antibody, C7H19orf62 antibody, 5430437P03Rik antibody, Merit40 antibody, BRISC and BRCA1 A complex member 1 antibody, BRISC and BRCA1 A complex member 1 L homeolog antibody, babam1 antibody, BABAM1 antibody, babam1.L antibody, Babam1 antibody
    背景
    BRISC and BRCA1 A complex member 1 , C19orf62 , HSPC142 , MERIT40 , NBA1,Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
    分子量
    37 kDa
    基因ID
    29086
    UniProt
    Q9NWV8
    途径
    Positive Regulation of Response to DNA Damage Stimulus
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