TRIM72 抗体
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- 抗原 See all TRIM72 抗体
- TRIM72 (Tripartite Motif Containing 72 (TRIM72))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRIM72 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠
- 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human TRIM72. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product TRIM72 Primary Antibody
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- 应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Validation: Orthogonal
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.42 mg/mL
- 缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- TRIM72 (Tripartite Motif Containing 72 (TRIM72))
- 别名
- tripartite motif containing 72 (TRIM72 产品)
- 别名
- Trim72 antibody, MG53 antibody, Mg53 antibody, BC067209 antibody, RGD1562778 antibody, tripartite motif containing 72 antibody, tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog antibody, tripartite motif-containing 72 antibody, TRIM72 antibody, trim72.L antibody, Trim72 antibody
- 背景
- Tripartite motif containing 72 , MG53,Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
- 分子量
- 53 kDa
- 基因ID
- 493829
- UniProt
- Q6ZMU5
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