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CIITA 抗体

CIITA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7464900
发货至: 中国
  • 抗原 See all CIITA 抗体
    CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
    适用
    • 18
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    • 2
    • 2
    • 1
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    • 1
    宿主
    • 20
    • 1
    克隆类型
    • 20
    • 1
    多克隆
    标记
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    This CIITA antibody is un-conjugated
    应用范围
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    交叉反应
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product CIITA Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: Raji , Raji NE

    Validation: Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.31 mg/mL
    缓冲液
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
    别名
    class II major histocompatibility complex transactivator (CIITA 产品)
    别名
    CIITA antibody, C2ta antibody, EG669998 antibody, Gm9475 antibody, C2TA antibody, CIITAIV antibody, MHC2TA antibody, NLRA antibody, Mhc2ta antibody, class II, major histocompatibility complex, transactivator antibody, class II major histocompatibility complex transactivator antibody, MHC class II transactivator antibody, class II transactivator antibody, CIITA antibody, LOC710761 antibody, ciita antibody, LOC100443575 antibody, Ciita antibody, LOC100736732 antibody
    背景
    Class II major histocompatibility complex transactivator , C2TA , CIITAIV , MHC2TA , NLRA,This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq]
    分子量
    124 kDa
    基因ID
    4261
    UniProt
    P33076
    途径
    Cancer Immune Checkpoints
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