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SELPLG 抗体

SELPLG 适用: 小鼠 FACS, BR 宿主: 大鼠 Monoclonal 4RA10 unconjugated
产品编号 ABIN7457881
发货至: 中国
  • 抗原 See all SELPLG 抗体
    SELPLG (Selectin P Ligand (SELPLG))
    适用
    • 75
    • 33
    • 20
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 67
    • 28
    • 13
    大鼠
    克隆类型
    • 64
    • 43
    • 1
    单克隆
    标记
    • 39
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    • 1
    • 1
    • 1
    • 1
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    This SELPLG antibody is un-conjugated
    应用范围
    • 64
    • 60
    • 22
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    • 16
    • 9
    • 9
    • 3
    • 2
    • 1
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    Flow Cytometry (FACS), Blocking Reagent (BR)
    纯化方法
    Purified
    克隆位点
    4RA10
    亚型
    IgG1, kappa
    Top Product
    Discover our top product SELPLG Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Matching Isotype Control: Purified Rat IgG1, κ Isotype Control (ABIN7469819)

    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS with 0.05 % Proclin300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2~8°C. Do not freeze.
  • 抗原
    SELPLG (Selectin P Ligand (SELPLG))
    别名
    CD162 (SELPLG 产品)
    背景
    P-selectin glycoprotein ligand 1,Selplg,PSGL-1,Selectin P ligand,CD162,The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
    基因ID
    20345
    UniProt
    Q62170
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