AKAP8L 抗体 (AA 596-646)
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- 抗原 See all AKAP8L 抗体
- AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
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抗原表位
- AA 596-646
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AKAP8L antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
- 原理
- Rabbit anti-AKAP8L/HA95 Antibody, Affinity Purified
- 纯化方法
- Affinity Purified
- 免疫原
- between AA 596 and 646
- 亚型
- IgG
- Top Product
- Discover our top product AKAP8L Primary Antibody
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- 应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
- 别名
- AKAP8L/HA95 (AKAP8L 产品)
- 别名
- HA95 antibody, HAP95 antibody, NAKAP antibody, NAKAP95 antibody, Nakap95 antibody, zgc:85966 antibody, AKAP8L antibody, A-kinase anchoring protein 8 like antibody, A kinase (PRKA) anchor protein 8-like antibody, A-kinase anchoring protein 8 like L homeolog antibody, AKAP8L antibody, Akap8l antibody, akap8l antibody, akap8l.L antibody
- 背景
- Background: AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington's disease.
- 基因ID
- 26993
- NCBI登录号
- NP_055186
- UniProt
- Q9ULX6
- 途径
- SARS-CoV-2 Protein Interactome
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