CAND1 抗体 (AA 1180-1230)
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- 抗原 See all CAND1 抗体
- CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))
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抗原表位
- AA 1180-1230
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CAND1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
- 原理
- Rabbit anti-CAND1 Antibody, Affinity Purified
- 预测反应
- Rat,Bovine,Orangutan
- 纯化方法
- Affinity Purified
- 免疫原
- between AA 1180 and 1230
- 亚型
- IgG
- Top Product
- Discover our top product CAND1 Primary Antibody
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- 应用备注
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
- 限制
- 仅限研究用
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- 浓度
- 1000 μg/mL
- 缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))
- 别名
- CAND1 (CAND1 产品)
- 背景
- Background: Cullin-associated NEDD8-dissociated protein 1 (CAND1) is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site and disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins. CAND1 also binds TATA binding protein and enhances transcription from various promoters [taken from the Universal Protein Resource (UniProt) Q86VP6].
- 基因ID
- 55832
- NCBI登录号
- NP_060918
- UniProt
- Q86VP6
- 途径
- Regulation of Actin Filament Polymerization
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