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FAM105B 抗体 (AA 75-125)

FAM105B 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7452665
发货至: 中国
  • 抗原 See all FAM105B products
    FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
    抗原表位
    • 7
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 75-125
    适用
    • 23
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 23
    克隆类型
    • 23
    多克隆
    标记
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    This FAM105B antibody is un-conjugated
    应用范围
    • 17
    • 16
    • 12
    • 12
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    原理
    Rabbit anti-OTULIN Antibody, Affinity Purified
    纯化方法
    Affinity Purified
    免疫原
    between AA 75 and 125
    亚型
    IgG
  • 应用备注

    IP: 20-40 μL/mg lysate

    WB: 1:2,000 - 1:10,000

    限制
    仅限研究用
  • 浓度
    1000 μg/mL
    缓冲液
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    有效期
    12 months
  • 抗原
    FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
    别名
    OTULIN (FAM105B 产品)
    别名
    C79097 antibody, OTU deubiquitinase with linear linkage specificity antibody, OTULIN antibody, Otulin antibody
    背景
    Background: Otulin is a deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. [taken from the Universal Protein Resource (UniProt) Q96BN8].
    基因ID
    90268
    UniProt
    Q96BN8
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