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TDP1 抗体 (AA 75-125)

TDP1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7452451
发货至: 中国
  • 抗原 See all TDP1 抗体
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    抗原表位
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 75-125
    适用
    • 41
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 34
    • 7
    • 1
    克隆类型
    • 37
    • 5
    多克隆
    标记
    • 28
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    This TDP1 antibody is un-conjugated
    应用范围
    • 36
    • 22
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunoprecipitation (IP)
    原理
    Rabbit anti-TDP1 Antibody, Affinity Purified
    纯化方法
    Affinity Purified
    免疫原
    between AA 75 and 125
    亚型
    IgG
    Top Product
    Discover our top product TDP1 Primary Antibody
  • 应用备注

    IP: 2 - 5 μg/mg lysate

    WB: Not recommended. Use rabbit anti-TDP1 antibody ABIN7453800.

    限制
    仅限研究用
  • 浓度
    1000 μg/mL
    缓冲液
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    有效期
    12 months
  • 抗原
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    别名
    TDP1 (TDP1 产品)
    别名
    2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody
    背景
    Background: Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3' phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3'-phosphoglycolate termini of double-stranded breaks and a variety of other 3'- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.
    基因ID
    55775
    NCBI登录号
    NP_001008744
    UniProt
    Q9NUW8
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