TNKS1BP1 抗体 (AA 350-400)
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- 抗原 See all TNKS1BP1 抗体
- TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))
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抗原表位
- AA 350-400
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TNKS1BP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 原理
- Rabbit anti-TAB182 Antibody, Affinity Purified
- 纯化方法
- Affinity Purified
- 免疫原
- between AA 350 and 400
- 亚型
- IgG
- Top Product
- Discover our top product TNKS1BP1 Primary Antibody
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- 应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))
- 别名
- TAB182 (TNKS1BP1 产品)
- 别名
- TAB182 antibody, Tab182 antibody, mKIAA1741 antibody, tankyrase 1 binding protein 1 antibody, 182 kDa tankyrase-1-binding protein antibody, TNKS1BP1 antibody, LOC100625088 antibody, Tnks1bp1 antibody
- 背景
- Background: TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
- 基因ID
- 85456
- NCBI登录号
- NP_203754
- UniProt
- Q9C0C2
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