CIZ1 抗体 (AA 325-375)
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- 抗原 See all CIZ1 抗体
- CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))
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抗原表位
- AA 325-375
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CIZ1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 原理
- Rabbit anti-CIZ1 Antibody, Affinity Purified
- 纯化方法
- Affinity Purified
- 免疫原
- between AA 325 and 375
- 亚型
- IgG
- Top Product
- Discover our top product CIZ1 Primary Antibody
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- 应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))
- 别名
- CIZ1 (CIZ1 产品)
- 别名
- LSFR1 antibody, NP94 antibody, ZNF356 antibody, CIZ1 antibody, 0610038H21Rik antibody, 2900056O04Rik antibody, ciz1 antibody, wu:fi12g11 antibody, wu:fi27d02 antibody, zgc:66467 antibody, CDKN1A interacting zinc finger protein 1 antibody, cip1-interacting zinc finger protein antibody, cdkn1a interacting zinc finger protein 1b antibody, CIZ1 antibody, LOC464765 antibody, Ciz1 antibody, ciz1b antibody
- 背景
- Background: CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.
- 基因ID
- 25792
- NCBI登录号
- NP_036259
- UniProt
- Q9ULV3
- 途径
- Maintenance of Protein Location
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