PAN3 抗体 (AA 175-225)
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- 抗原 See all PAN3 抗体
- PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))
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抗原表位
- AA 175-225
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAN3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 原理
- Rabbit anti-PAN3 Antibody, Affinity Purified
- 纯化方法
- Affinity Purified
- 免疫原
- Between AA 175 and 225
- 亚型
- IgG
- Top Product
- Discover our top product PAN3 Primary Antibody
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anti-PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3) (AA 771-799), (C-Term) antibody
PAN3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB25565 unconjugated
anti-PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3) (AA 727-755), (C-Term) antibodyPAN3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB34660 unconjugated
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- 应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
- 限制
- 仅限研究用
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- 浓度
- 1000 μg/mL
- 缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))
- 别名
- PAN3 (PAN3 产品)
- 别名
- 2700050F09Rik antibody, A430027N15Rik antibody, AU014670 antibody, pan3 antibody, zgc:171628 antibody, PAN3 poly(A) specific ribonuclease subunit antibody, PAN3 poly(A) specific ribonuclease subunit S homeolog antibody, PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) antibody, Pan3 antibody, PAN3 antibody, pan3.S antibody, pan3 antibody
- 背景
- Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) Q58A45].
- 基因ID
- 255967
- UniProt
- Q58A45
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