RFWD2 抗体 (AA 1-50)
-
- 抗原 See all RFWD2 抗体
- RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
-
抗原表位
- AA 1-50
-
适用
- 人, 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This RFWD2 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 原理
- Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified
- 纯化方法
- Affinity Purified
- 免疫原
- Between AA 1 and 50
- 亚型
- IgG
- Top Product
- Discover our top product RFWD2 Primary Antibody
-
-
- 应用备注
-
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
- 限制
- 仅限研究用
-
- 浓度
- 200 μg/mL
- 缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
-
- 抗原
- RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
- 别名
- COP1/RFWD2 (RFWD2 产品)
- 别名
- COP1 antibody, RNF200 antibody, AI316802 antibody, C80879 antibody, Cop1 antibody, RGD1304773 antibody, RFWD2 antibody, cop1 antibody, rnf200 antibody, zgc:163067 antibody, ring finger and WD repeat domain 2 antibody, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase antibody, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog antibody, RFWD2 antibody, Rfwd2 antibody, rfwd2 antibody, rfwd2.L antibody
- 背景
- Background: Constitutive photomorphogenic protein 1 (COP1) has been characterized in plants as a RING-finger-containing protein that functions to repress plant photomorphogenesis. In mammals, COP1 has been identified as an E3 ubiquitin ligase that negatively regulates p53 protein levels in unstressed cells. In response to DNA damage COP1 is phosphorylated by the ataxia telangiectasia mutated (ATM) protein kinase and is rapidly degraded releasing p53 to exert its tumor suppressor activities.
- 基因ID
- 64326
- NCBI登录号
- NP_071902
- UniProt
- Q8NHY2
- 途径
- Photoperiodism
-