MHC Class II HLA-DP/DQ/DR 抗体
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- 抗原 See all MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR) products
- MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MHC Class II HLA-DP/DQ/DR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- 原理
- Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]
- 免疫原
- Cells from human tonsil
- 克隆位点
- CR3-43
- 亚型
- IgG
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- 应用备注
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IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
WB: 01:01,00
- 限制
- 仅限研究用
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- 浓度
- 250 μg/mL
- 缓冲液
- Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
- 别名
- HLA-DR/DP/DQ (HLA-DP/DQ/DR 产品)
- 背景
- Background: In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ~70 % similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.
- 基因ID
- 3122
- NCBI登录号
- NP_061984
- UniProt
- P01903
- 途径
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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