ct90 antibody, mpp1 antibody, krmp1 antibody, mpp-1 antibody, MGC83846 antibody, mphosph1 antibody, KIF20B antibody, MPHOSPH1 antibody, CT90 antibody, KRMP1 antibody, MPP-1 antibody, MPP1 antibody, B130024C23 antibody, C330014J10Rik antibody, Mphosph1 antibody, kinesin family member 20B S homeolog antibody, kinesin family member 20B antibody, kif20b.S antibody, KIF20B antibody, kif20b antibody, Kif20b antibody
背景
Background: Kinesin family member 20B (KIF20B) is a plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). KIF20B is required for proper midbody organization and abscission in polarized cortical stem cells. It plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. KIF20B participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, KIF20B cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. It is involved in cerebral cortex growth (By similarity). KIF20B acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). [taken from the Universal Protein Resource (UniProt) Q96Q89].