zgc:55840 antibody, SPF45 antibody, 2700027J02Rik antibody, RNA binding motif protein 17 antibody, RNA binding motif protein 17 L homeolog antibody, Rbm17 antibody, rbm17 antibody, RBM17 antibody, rbm17.L antibody
背景
Background: Splicing factor 45 (SPF45) is an RNA splicing factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. SPF45 is involved in the regulation of alternative splicing and the utilization of cryptic splice sites. It has been shown to promote the utilization of a cryptic splice site created by the beta-110 mutation in the human beta-thalassemia gene. The resulting frameshift leads to sickle cell anemia [taken from the Universal Protein Resource (UniProt) Q96125].