eml4 antibody, MGC89332 antibody, EML4 antibody, C2orf2 antibody, ELP120 antibody, EMAP-4 antibody, EMAPL4 antibody, ROPP120 antibody, 4930443C24Rik antibody, AI644019 antibody, echinoderm microtubule associated protein like 4 antibody, echinoderm microtubule associated protein like 4 S homeolog antibody, Eml4 antibody, EML4 antibody, eml4 antibody, eml4.S antibody
背景
Background: Echinoderm microtubule associated protein like 4 (EML4) has been identified as part of a gene fusion with the kinase domain of the anaplastic lymphoma receptor tyrosine kinase (ALK) in non-small cell lung cancer. EML4 associates with in vitro polymerized microtubules. In the cell, phosphorylated EML4 associates with the mitotic spindle and is essential for proliferation and microtubule network formation.