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- 抗原 See all APEX2 抗体
- APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
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抗原表位
- AA 301-400
- 适用
- 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This APEX2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Human
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human APEX2
- 亚型
- IgG
- Top Product
- Discover our top product APEX2 Primary Antibody
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anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) (AA 143-171) antibody
APEX2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23043 unconjugated
anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) (AA 1-518) antibodyAPEX2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) antibodyAPEX2 适用: 人 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
- 别名
- APEX2 (APEX2 产品)
- 别名
- APE2 antibody, APEXL2 antibody, XTH2 antibody, ape2 antibody, apexl2 antibody, xth2 antibody, zgc:55889 antibody, C430040P13Rik antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 antibody, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog antibody, apurinic/apyrimidinic endonuclease 2 antibody, APEX2 antibody, apex2 antibody, apex2.L antibody, Apex2 antibody
- 背景
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Synonyms: APE2, XTH2, ZGRF2, APEXL2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2
Background: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
- 基因ID
- 27301
- UniProt
- Q9UBZ4
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