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RSV Fusion Protein 抗体

RSV F 适用: Respiratory Syncytial Virus (RSV) ELISA 宿主: 兔 Monoclonal 9 unconjugated
产品编号 ABIN7383841
发货至: 中国
  • 抗原 See all RSV Fusion Protein (RSV F) products
    RSV Fusion Protein (RSV F) (Respiratory Syncytial Virus Fusion Protein (RSV F))
    适用
    Respiratory Syncytial Virus (RSV)
    宿主
    • 13
    • 1
    克隆类型
    • 14
    单克隆
    标记
    • 14
    This RSV Fusion Protein antibody is un-conjugated
    应用范围
    • 10
    • 6
    • 4
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    • 3
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    • 1
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    ELISA
    特异性
    Anti-Human respiratory syncytial virus(RSV) Fusion Glycoprotein/RSV-F Monoclonal Antibody
    纯化方法
    Protein A Affinity
    免疫原
    Recombinant RSV (A2) Fusion glycoprotein / RSV-F Protein (His Tag), ABIN7198760
    克隆位点
    9
    亚型
    IgG
  • 应用备注
    ELISA 1:1000-1:2000
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    0.2 μm filtered solution in PBS
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    RSV Fusion Protein (RSV F) (Respiratory Syncytial Virus Fusion Protein (RSV F))
    别名
    respiratory syncytial virus(RSV) Fusion Glycoprotein/RSV-F (RSV F 产品)
    背景
    F,HRSVgp08,Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. The G protein mediates attachment of the virus to cell surface receptors, while the F protein promotes fusion of the viral and cellular membranes, allowing entry of the virus ribonucleoprotein into the cell cytoplasm. The fusion (F) protein of RSV is synthesized as a nonfusogenic precursor protein (F), which during its migration to the cell surface is activated by cleavage into the disulfide-linked F1 and F2 subunits. This fusion is pH independent and occurs directly at the outer cell membrane, and the F2 subunit was identifed as the major determinant of RSV host cell specificity. The trimer of F1-F2 interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and induces the fusion between host cell and virion membranes. Notably, RSV fusion protein is unique in that it is able to interact directly with heparan sulfate and therefore is sufficient for virus infection. Furthermore, the fusion protein is also able to trigger p53-dependent apoptosis.
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