GP120 抗体
HIV-1 gp120
适用: Human Immunodeficiency Virus (HIV)
ELISA
宿主: 小鼠
Monoclonal
4F4E4
unconjugated
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- 抗原 See all GP120 (HIV-1 gp120) 抗体
- GP120 (HIV-1 gp120) (Human Immunodeficiency Virus 1 Surface Glycoprotein (HIV-1 gp120))
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适用
- Human Immunodeficiency Virus (HIV)
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GP120 antibody is un-conjugated
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应用范围
- ELISA
- 特异性
- Anti-HIV-1 gp120 Protein(group M, subtype CRF07_BC) Monoclonal Antibody
- 纯化方法
- Protein A Affinity
- 免疫原
- Recombinant HIV-1 gp120 Protein (group M, subtype CRF07_BC) (His Tag), ABIN7196135
- 克隆位点
- 4F4E4
- 亚型
- IgG2b
- Top Product
- Discover our top product HIV-1 gp120 Primary Antibody
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- 应用备注
- ELISA 1:1000-1:2000
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- 0.2 μm filtered solution in PBS
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- GP120 (HIV-1 gp120) (Human Immunodeficiency Virus 1 Surface Glycoprotein (HIV-1 gp120))
- 别名
- HIV-1 gp120 Protein(group M, subtype CRF07_BC) (HIV-1 gp120 产品)
- 背景
- Gp120,The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, which is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 Molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp12 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.
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