This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015],KMT3F, KMT3G, WHISTLE, WHSC1L1, pp14328,Epigenetics & Nuclear Signaling,NSD3