PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Store at -20°C. Avoid freeze / thaw cycles.
抗原
USP37
(Ubiquitin Specific Peptidase 37 (USP37))
别名
USP37
背景
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2. Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.,USP37,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP37