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Tppp 抗体

Tppp 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7271031
发货至: 中国
  • 抗原 See all Tppp 抗体
    Tppp (Tubulin Polymerization Promoting Protein (Tppp))
    适用
    • 41
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    • 7
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    • 2
    • 1
    宿主
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    • 1
    克隆类型
    • 56
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    单克隆
    标记
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    This Tppp antibody is un-conjugated
    应用范围
    • 51
    • 25
    • 13
    • 13
    • 9
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    TPPP/p25 Rabbit mAb
    交叉反应
    小鼠, 大鼠
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthesized peptide derived from human TPPP/p25
    亚型
    IgG
    Top Product
    Discover our top product Tppp Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Tppp (Tubulin Polymerization Promoting Protein (Tppp))
    别名
    TPPP (Tppp 产品)
    别名
    TPPP/p25 antibody, TPPP1 antibody, p24 antibody, p25 antibody, p25alpha antibody, 2900041A09Rik antibody, AI849835 antibody, RGD1310121 antibody, tubulin polymerization promoting protein antibody, TPPP antibody, Tppp antibody
    背景
    Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity, the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network. Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6. Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility. Plays a role in cell proliferation by regulating the G1/S-phase transition. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis, this process is regulated by phosphorylation by LIMK2.,TPPP/p25, TPPP1, p24, p25, p25alpha,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microtubules,Signal Transduction,TPPP
    分子量
    25kDa
    基因ID
    11076
    UniProt
    O94811
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