The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene.,TRMT2A, HTF9C, tRNA methyltransferase 2 homolog A,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Tumor biomarkers,HTF9C