Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity.,KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1,Apoptosis,Cancer,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Signal Transduction,Tumor suppressors,Tumor suppressors_p53 pathway,PERP